PROTARCH


A system of computer programs for hierarchical prediction of protein structure based on the thermodynamic hypothesis. The key stage of the method is global optimization of the energy of a polypeptide chain at the simplified united-residue level. This task is carried out with the use of the UNRES force field and the Conformational Space Annealing (CSA) method. PROTARCH includes also computational tools to carry out cluster analysis and construction of all-atom backbone from the united-residue chain using the dipole-path method.


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